Urolithin A

Product Introduction

Urolithin A (CAS: 1143-70-0) is a premium ingredient for testing in topical skincare applications. It integrates beautifully into rich night creams, leave-on face masks, and barrier-support emulsions. On a technical level, this compound boasts remarkable heat stability, meaning it won’t break down during warm emulsification processes. Since raw Urolithin A is lipophilic with low water solubility, dispersing it in lipid-based carriers or liposomal systems ensures optimal suspension and delivery in your final base. These properties make the material ideal “for formulation evaluation” in complex emulsion matrices. As with all novel ingredients, buyers should confirm local regulatory requirements before commercialization.

Product Characteristics

• Precision Mitochondrial Targeting: It is one of the very few natural molecules proven to cross cellular barriers and specifically trigger “mitophagy”—the selective clearance of damaged mitochondria to make way for healthy, newly generated ones.
• Bypassing Gut Microbiome Limits: Research shows that only about 30% to 40% of people possess the specific gut microbiome required to convert dietary ellagitannins into Urolithin A. Direct supplementation bypasses this microbial bottleneck, delivering immediate benefits to everyone.
• Excellent Physical & Chemical Stability: Appearing as a pale-yellow to off-white crystalline powder, it displays exceptional stability against heat, light, and air, making it highly compatible with various formulation types.
• Clinically Validated & GRAS Status: Backed by multiple human clinical trials demonstrating its efficacy in boosting muscle strength and endurance, it has successfully secured US FDA GRAS (Generally Recognized as Safe) status.

Product Uses

1. Combats Muscle Aging & Sarcopenia: By optimizing mitochondrial energy output, it significantly reverses muscle decline associated with aging or physical inactivity, restoring muscle contractility and fatigue resistance.
2. Boosts Physical Endurance: It enhances maximum oxygen consumption (VO2 max) during aerobic exercise and accelerates muscle fiber recovery post-workout, serving as a natural performance booster for athletes and fitness enthusiasts.
3. Promotes Systemic Longevity: By revitalizing cell powerhouses, it effectively curtails systemic inflammation (“inflammaging”) and delays the degenerative aging of the cardiovascular system, brain, and skin.
4. Enhances Metabolic Health: It improves cellular insulin sensitivity, supports healthy lipid metabolism, and helps prevent various chronic metabolic issues stemming from mitochondrial dysfunction.

Application Scenarios

• Longevity brands feature Urolithin A as a crown-jewel active ingredient in premium capsules, liquid shots, and tablets aimed at “cellular rejuvenation, mitochondrial repair, and anti-aging.” It is frequently paired with NMN, PQQ, or Coenzyme Q10 to create powerhouse synergistic formulas.

• Sports nutrition innovators incorporate it into protein powders, pre-workout formulas, and muscle recovery capsules targeted at athletes, fitness enthusiasts, and seniors. It targets muscle fibers directly to rebuild strength and slash recovery times after high-intensity training.

• Cosmetic and hair-care chemists formulate Urolithin A into luxury facial serums, restoring night creams, and anti-aging scalp tonics. It directly boosts mitochondrial activity in skin cells and hair follicles, accelerating barrier repair, restructuring collagen, and delaying skin sagging.

• Following its rigorous safety clearances, food tech giants are infusing Urolithin A into energy bars, meal replacement shakes, ready-to-drink (RTD) functional beverages, and fortified dairy products, making “cellular-level aging intervention” a seamless part of daily nutrition.