Product Introduction
Pramipexole Dihydrochloride (CAS：191217-81-9)acts as a vital building block and chemical synthesis intermediate, primarily used for laboratory research and process development. In manufacturing evaluation, it serves as a reliable starting material for preparing advanced inorganic complexes and coordination compounds. Our product features outstanding batch consistency and strict impurity control, supported by comprehensive COA and MSDS documentation for precise purity review. Physically, this powder maintains excellent chemical stability when sealed and kept in a cool, dry warehouse. It offers highly predictable reactivity during synthesis trials, making it ideal for formulating consistent experimental batches. Buyers should confirm local regulatory requirements before purchasing.
CAS:191217-81-9
Properties: White or off-white crystalline powder; odorless, slightly bitter in taste; hygroscopic.
Solubility: readily soluble in: methanol, dilute hydrochloric acid, DMSO; slightly soluble in: ethanol, water; almost insoluble in: acetone, ethyl acetate, ether, chloroform
Purity: ≥99.0%
Melting point: 282–286°C (decomposition)
Purpose: Pharmaceutical active ingredient: Selective dopamine D₂/D₃ receptor agonist, indicated for: treatment of Parkinson’s disease and moderate-to-severe restless legs syndrome. Mechanism of action: Directly agonizes dopamine receptors, alleviates motor symptoms, and reduces levodopa fluctuations.
Storage conditions: Store in a sealed container, protected from light, in a dry and cool place; temperature 10–25°C; protect from moisture and oxidation.
Product Characteristics
- High Selectivity: It binds selectively to dopamine D2 and D3 receptors. It has a strong preference for D3 receptors, which directly improves motor symptoms.
- Fast Absorption: The body absorbs it quickly and completely after oral intake. Its absolute bioavailability exceeds 90%.
- Safer Structure: As a non-ergoline derivative, it does not cause fibrotic heart valve issues.
- Dual Benefits: It controls tremors and improves movement. At the same time, it helps ease depression and anxiety in Parkinson’s patients.
- No Liver Metabolism: The kidneys excrete the drug mostly unchanged. This feature minimizes drug-to-drug interactions in the liver.
Product Uses
- Parkinson’s Disease Treatment: It serves as a first-line therapy for Parkinson’s disease. Patients can use it alone or with levodopa. It lowers the needed dose of levodopa and reduces motor fluctuations.
- Restless Legs Syndrome (RLS) Treatment: It relieves the painful urge to move the legs during the night. This greatly improves sleep quality for RLS patients.
Application Scenarios
- First-line Neurology Prescriptions: Neurologists prescribe it to delay the use of levodopa and protect the patients’ neurological functions.
- Extended-Release (ER) Development: Drug manufacturers use it to develop once-daily extended-release tablets. This formulation provides stable drug levels and simplifies the dosing schedule.
- API Sourcing for Generics: Pharmaceutical companies purchase this high-quality Active Pharmaceutical Ingredient (API) for bioequivalence studies and commercial tablet production.
