Product Introduction
Sunitinib Intermediate 7 (CAS: 356068-93-4) serves as a key building block in synthesizing multi-targeted receptor tyrosine kinase inhibitors and related oncology research candidates. This high-purity pyrrole derivative offers excellent reactivity in Knoevenagel condensation steps, accelerating process development without complex purification. In-house manufacturing evaluations confirm that its low residual solvent profile prevents degradation and ensures consistent reaction yields. Backed by stringent impurity control and fully audited COA/MSDS documentation, our material guarantees superior batch consistency. Store this light-sensitive solid under nitrogen in a cool, dark place to maintain shelf-life stability.
CAS:356068-93-4
Properties: Yellow to deep orange crystalline powder, solid state, no special irritating odor, stable under normal conditions.
Solubility: Slightly soluble in water, dimethyl sulfoxide (soluble upon heating), almost insoluble in weakly polar organic solvents such as n-hexane and petroleum ether.
Melting point: 320℃ (melting decomposition)
Usage: Core intermediate for the synthesis of sunitinib malate, a key fragment for constructing the sunitinib mother nucleus structure. Subsequently, it undergoes amidation reaction to generate sunitinib base, widely used in the research and development of anti-tumor targeted drugs and the production of raw materials for advanced renal cell carcinoma, gastrointestinal stromal tumors, etc. It can also be used as a reference standard for sunitinib-related impurities.
Storage conditions: Store in a sealed container, protected from light, in a dry place at room temperature, away from oxidants, strong acids and strong bases, and avoid high temperature, high humidity, and direct strong light.
Product Characteristics
- Pyrrole Core: The molecule contains a substituted pyrrole ring.
- High Reactivity: The active formyl group reacts quickly.
- Physical Appearance: It exists as a light yellow to brown solid.
- Good Solubility: It dissolves easily in common organic solvents.
Product Uses
- Sunitinib Synthesis: It serves as the vital block for Sunitinib.
- Kinase Inhibitors: Researchers use it to develop tyrosine kinase inhibitors.
- Pyrrole Derivatives: Chemists use it to prepare functional pyrrole compounds.
Application Scenarios
- API Manufacturing: Pharmaceutical factories buy it for large-scale production.
- Oncology R&D: Cancer research labs use it to design therapies.
- Contract Synthesis: CRO companies use it for custom chemical synthesis.
