Product Introduction
Tofacitinib Citrate (CAS: 540737-29-9) is a premium chemical synthesis intermediate and crucial building block, specifically utilized in process development and academic research. It serves as an essential starting material for manufacturing evaluation and synthesizing bio-active assays. We maintain rigorous impurity control and superb batch consistency, with detailed COA and MSDS documentation supplied for thorough purity review. Technically, this compound demonstrates excellent solubility characteristics in polar organic solvents and highly predictable thermal stability during pilot-scale synthesis. Storing the material in tightly sealed containers at 2-8°C ensures prolonged shelf-life and steady reactivity. Buyers must verify local regulatory compliance prior to ordering.
CAS:540737-29-9
Properties: White to off-white crystalline powder; odorless; hygroscopic.
Solubility: readily soluble in dimethyl sulfoxide and methanol 、Soluble in water and ethanol 、Slightly soluble in ethyl acetate 、Almost insoluble in n-hexane and ether
Melting point: 125–130°C
Purpose: JAK kinase inhibitor， For moderate to severe active rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis
Storage conditions: Keep sealed, protected from light, and stored in a cool, dry place; temperature 10–25°C; protect from moisture, light, and oxidizing agents.
Product Characteristics
- Targeted Action: It selectively inhibits JAK1 and JAK3 pathways. This action directly blocks key inflammatory signals.
- Oral Convenience: Unlike injectable biologics, it is an oral tablet. Patients can manage their treatment easily at home.
- Fast Relief: Most patients experience a significant reduction in joint pain and swelling within 2 to 6 weeks.
- No Anti-Drug Antibodies: As a small molecule, it does not trigger anti-drug antibodies in the body. Therefore, it maintains stable efficacy over long-term use.
Product Uses
- Rheumatoid Arthritis (RA) Treatment: It treats moderate-to-severe active RA in patients who respond poorly to methotrexate.
- Ankylosing Spondylitis (AS) Treatment: It reduces inflammation in the spine and joints, improving the patient’s daily mobility.
- Psoriatic Arthritis (PsA) Treatment: It simultaneously relieves both skin plaques and joint pain.
- Ulcerative Colitis (UC) Treatment: It helps heal the colon lining in patients with moderate-to-severe active UC.
Application Scenarios
- Alternative Therapy in Rheumatology & Gastroenterology: Specialists prescribe it when patients do not respond to traditional DMARDs or TNF-alpha blockers.
- Once-Daily Extended-Release (XR) Development: Drug manufacturers use it to develop 11mg once-daily tablets for better patient compliance.
- API Sourcing for Generic Drug Production: Pharmaceutical companies purchase this Active Pharmaceutical Ingredient (API) for bioequivalence studies and generic drug manufacturing.
