Hexamidine diisethionate

Product Introduction

Hexamidine diisethionate (CAS: 659-40-5) serves as a mild, multifunctional purifying in personal care development. It is highly suitable for clarifying facial cleansers, anti-dandruff shampoos, scalp-soothing serums, and deodorant formulations. Technically, this crystalline powder is highly water-soluble and maintains excellent thermal stability up to 80°C. It functions efficiently across a broad pH range of 3.0 to 6.5 and shows great compatibility with cationic and non-ionic surfactant systems without affecting foam quality. This makes it a reliable candidate “for formulation evaluation” in mild hygiene products. Buyers should confirm local regulatory requirements before importing.

Product Characteristics

• Broad-Spectrum Antimicrobial Power: It exhibits exceptional inhibitory and bactericidal activity against dandruff-causing fungi (Malassezia), acne-causing bacteria (Cutibacterium acnes), and a wide range of Gram-positive and Gram-negative bacteria.
• Exceptional Mildness & Safety: Unlike traditional anti-dandruff actives (like ZPT) or harsh anti-acne agents (like salicylic acid), it has extremely low irritation potential for the skin and mucous membranes. It preserves the skin’s natural barrier, making it ideal for sensitive skin and delicate scalps.
• Excellent Water Solubility & Formulating Stability: It dissolves completely in water and glycols. It requires no hot processing and maintains outstanding chemical stability without discoloration across a wide pH range (3.0–8.0).
• High Formulation Compatibility: As a cationic compound, it integrates seamlessly with non-ionic and amphoteric surfactants, as well as most thickeners, making it highly suitable for clear, transparent formulations.

Product Uses

1. Targeted Anti-Dandruff & Anti-Itch: It targets and inhibits the overgrowth of Malassezia yeast to eliminate dandruff and scalp itching at the source while soothing scalp irritation.
2. Gentle Acne Control: It penetrates deep into hair follicles to suppress Cutibacterium acnes, reducing red, inflamed blemishes and preventing blackheads without causing dryness or peeling.
3. Preservative Boosting & “Preservative-Free” Claims: Thanks to its robust antimicrobial profile, it serves as an excellent preservative booster, drastically reducing the needed dose of traditional preservatives and supporting “preservative-free” marketing claims.
4. High-Performance Deodorization: It inhibits the skin surface bacteria responsible for decomposing sweat, thereby neutralizing body and foot odor for long-lasting freshness.

Application Scenarios

• It is widely used in silicone-free anti-dandruff shampoos, soothing scalp serums, and leave-on scalp conditioners. As a superior alternative to ZPT (which faces environmental and regulatory bans in various regions), it offers a gentler, non-stripping approach to balancing the scalp microbiome.

• Cosmetic chemists incorporate it into acne-clearing gels, anti-blemish toners, clarifying cleansers, and oil-control lotions for sensitive skin. It combats acne effectively while avoiding the stinging, peeling, and redness associated with traditional acne treatments.

• Due to its excellent safety profile, it is commonly formulated in premium baby wipes, waterless hand sanitizers, baby lotions, and feminine intimate washes. It delivers mild antibacterial protection while acting as a safe alternative to traditional preservatives, minimizing allergy risks.

• Roll-on deodorants, body sprays, antibacterial body washes, and post-workout cleansing gels utilize it as a core active to control body odor for extended periods without interfering with natural sweat gland functions.